21C Museum Hotel

You could call 21C Museum Hotel a 90-room boutique property. But it's also a museum of twenty-first-century art, an award-winning restaurant, and a cultural center at the heart of Museum Row in Louisville, Kentucky. Travel + Leisure called it "one of the most ambitious unions of art and hospitality ever undertaken."

Over 5,000 square feet of art-filled event space includes one large atrium for seated groups of up to 120 and receptions for up to 450; four conference rooms for 10 to 60; a high-tech boardroom for 12; and, for residential-style entertaining, a private penthouse with soaring river views. Catering draws on the talent at the hotel's signature restaurant, Proof on Main, which features modern American cuisine rich in Tuscan influences and the agricultural bounty of the Ohio River Valley.